|
KMID : 0387720110220010065
|
|
Korean Journal of Blood Transfusion
2011 Volume.22 No. 1 p.65 ~ p.69
|
|
|
A Case of Cimetidine-induced Immune Hemolytic Anemia
|
|
Lee Ye-Rim
So Hee-Jin
Chang Yoon-Hwan
Cho Su-Yeon
Back Dae-Hyun
Lim Kyung Ah
Hyun Jeong-Won
Han Kyou-Sup
Kang Hye-Jin
|
|
|
Abstract
|
|
|
|
There have been 5 case reports about immune hemolytic anemia related with cimetidine, but there has been no such report in Korea. A sixty-four-year-old woman was admitted to the emergency department in a coma. She was diagnosed with diffuse large B-cell lymphoma 5 years ago and she achieved a complete remission after treatment. She was in a state of shock, and her blood pressure was 70/40 mmHg. The laboratory test results were consistent with hemolytic anemia (HA) as follows: hemoglobin: 1.9 g/dL, corrected reticulocyte count: 2%, total/conjugated bilirubin: 6.4/2.1 mg/dL, lactate dehydrogenase: 1,083 U/L and haptoglobin ＜10 mg/dL. She had a history of taking the drugs including cimetidine, acetaminophen and etizolam for two days. She urgently received transfusion of 3 units of packed red blood cells and then she regained consciousness. To investigate the relation between cimetidine and HA, we subsequently performed a drug-induced immune complex test and an antibody test by using cimetidine, AB serum and phosphate-buffered saline. The results proved that cimetidine was the cause of the HA. Patient was treated with steroid, and the following laboratory tests showed rapid improvement. This is the first case report from Korea that shows the causal relationship between cimetidine and immune HA.
|
|
|
KEYWORD
|
|
|
Hemolytic anemia, Cimetidine, Drug-induced
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|